The Ena/VASP enigma.
نویسندگان
چکیده
Ena/VASP proteins are actin-binding proteins that localize to actin stress fibres, the tips of filopodia and the lamellipodial leading edge. In the past few years, a number of seemingly conflicting studies have confused the Ena/VASP field, pointing to roles for these proteins in both promotion and inhibition of actin-dependent processes. Recent discoveries resolve these contradictions and suggest a novel mechanism of Ena/VASP function, in which the proteins function as 'anti-capping' proteins that antagonize capping proteins at the barbed end of actin filaments.
منابع مشابه
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ورودعنوان ژورنال:
- Journal of cell science
دوره 115 Pt 24 شماره
صفحات -
تاریخ انتشار 2002